![]() This is in contrast to cortisol's effect in the skeletal muscle where glycogenolysis is promoted indirectly through catecholamines. Cortisol is thus better thought of as stimulating glucose/glycogen turnover in the liver. Paradoxically, cortisol promotes not only gluconeogenesis in the liver, but also glycogenesis. Additionally, cortisol facilitates the activation of glycogen phosphorylase, which is necessary for adrenaline to have an effect on glycogenolysis. Ĭortisol also plays an important, but indirect, role in liver and muscle glycogenolysis (the breaking down of glycogen to glucose-1-phosphate and glucose) which occurs as a result of the action of glucagon and adrenaline. ![]() ![]() Cortisol has a permissive effect on the actions of hormones that increase glucose production, such as glucagon and adrenaline. The net effect is an increase in the concentration of glucose in the blood, further complemented by a decrease in the sensitivity of peripheral tissue to insulin, thus preventing this tissue from taking the glucose from the blood. In general, cortisol stimulates gluconeogenesis (the synthesis of 'new' glucose from non-carbohydrate sources, which occurs mainly in the liver, but also in the kidneys and small intestine under certain circumstances). Health effects Metabolic response Metabolism of glucose
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